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Updated: May 19, 2026

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
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ゲノム損失によって明らかにされた癌の脆弱性

Deepak Nijhawan1, Travis I Zack, Yin Ren

  • 1Departments of Cancer Biology and Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.

Cell
|August 21, 2012
PubMed
まとめ

癌細胞はゲノムの不安定性を悪用し,遺伝子の複製番号の喪失につながります. 研究者らは,PSMC2のような,がん細胞の生存に不可欠な脆弱性を生み出す56のCYCLOPS (部分喪失によるがんの負債を生むコピー番号の変異) 遺伝子を特定しました.

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