モーターセンサリープロジェクションにおける活動は,体感覚における分布したコーディングを明らかにする
Leopoldo Petreanu1, Diego A Gutnisky, Daniel Huber
1Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA.
Nature
|August 28, 2012
まとめ
ソマトセンサリー皮質への皮質フィードバックは,ひげの動きや触覚に関する文脈的な情報を運ぶ. これにより,マウスは,アクティブタッチを使用してオブジェクトの位置づけとナビゲーションのための感覚データを統合することができます.
科学分野:
- 神経科学は神経科学である.
- 感覚処理は,感覚を処理するプロセスです.
- 皮質回路は,皮質回路である.
背景:
- 感覚領域への皮質フィードバックの投影は,主に層1 (L1) をターゲットとしています.
- L1入力では,文脈的な情報を伝達すると仮定されていますが,その特定の信号は特徴づけられていません.
- ネズミの体感覚系では,振動性運動皮質 (vM1) から振動性体感覚皮質 (vS1) へのフィードバックが,オブジェクトの局所化のために,ひげの位置とタッチを統合することがあります.
研究 の 目的:
- vM1からvS1.1までのL1フィードバックプロジェクションによって送信される信号の特徴を特定する.
- これらのフィードバックシグナルがマウスの口ひげに依存したオブジェクトのローカライゼーションにどのように寄与するかを調査する.
主な方法:
- バレル皮質のL1のvM1-->vS1アフェレンスの活動を追跡するために,軸索カルシウムイメージングを使用しました.
- 実験は,マウスがひげに依存するオブジェクトのローカライゼーションタスクを実行している間に行われました.
主要な成果:
- L1の個々の軸索は,ひげの動き,触覚,その他の行動特性を表しています.
- アクソンのサブセットは,オブジェクトの位置に依存する活動を示し,触れた後も持続しました.
- これらの発見は,L1フィードバックが統合された感覚情報を運ぶことを示唆しています.
結論:
- バルレル皮質のニューロンは,ひげの動きや時間とともに触れたことについての情報を受信します.
- この統合された情報は,アクティブタッチによるオブジェクト識別とナビゲーションに不可欠です.
- L1フィードバックは,複雑な行動のための文脈的な感覚データを処理する上で重要な役割を果たします.
さらに関連する動画
関連する概念動画
Somatosensation
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Motor and Sensory Areas of the Cortex
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Sensory Perception: Organization of the Somatosensory System
The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
Overview of Somatic Sensory Pathways
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
Major Somatic Sensory Pathways
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
Somatosensory, Motor, and Association Cortex
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...


