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Updated: May 19, 2026

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States
04:37

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States

Published on: June 29, 2021

折りたたみ時のタンパク質骨幹のエントロピーの損失の文脈と力場依存性,現実的なデナチュア化とネイティブ状態のアンサンブルを使用して折りたたむ

Michael C Baxa1, Esmael J Haddadian, Abhishek K Jha

  • 1Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States.

Journal of the American Chemical Society
|August 30, 2012
PubMed
まとめ

タンパク質の折りたたみにより,骨幹の形状が著しく低下し,残留物あたり平均0.7-1.1 kcal·mol(-1) のエントロピー損失が発生する. この研究では,以前の推定値とは異なる現実的なモデルを使用して,構成エントロピーの損失を定量化しています.

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