α/βペプチドによるタンパク質βシートにおけるサイドチェーン表示の配列ベースのミミクリのための設計戦略

George A Lengyel1, W Seth Horne

  • 1Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

PubMed
まとめ

研究者は,タンパク質シート構造を模倣する非自然な脊椎オリゴマーの設計のための新しい方法を開発しました. テストされた4つの戦略のうち3つは,より大きなタンパク質での潜在的な使用のために,折り畳みとネイティブサイドチェーンディスプレイの両方を成功裏に保持しました.

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