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大動脈の硬化,血圧の進行,および発生性高血圧
Bernhard M Kaess1, Jian Rong, Martin G Larson
1National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.
JAMA
|September 6, 2012
まとめ
大動脈の硬化と前向きの波幅の上昇は,高血圧と高血圧リスクの上昇を予測します. しかし,初期血圧は,将来の大動脈硬化を予測することはできず,硬さが高血圧の発症の重要な要因であることを強調しています.
科学分野:
- 心血管研究に関する研究.
- 老化と健康について
- 高血圧の研究は,高血圧の研究である.
背景:
- 血管の硬さは年齢とともに増加し,罹病率と死亡率に重大なリスクをもたらします.
- 血管の硬化と高血圧の間の一時的な関連は,さらに明確にする必要があります.
研究 の 目的:
- 血管の硬直性,中央血動力学,マイクロ血管機能,血圧の進行の間の時間的関係を調査する.
- 血管の硬さの測定が将来の血圧と高血圧をどのように予測するかを分析する.
主な方法:
- フレーミングハム・オフスプリング研究 (N=1759) のデータを用いた地域社会ベースの縦断的なコホート研究.
- 7年間の間に血圧と3つの血管の硬さ測定値 (動脈動脈脈波速度 [CFPWV],前向きの波幅 [FWA],増幅指数) の間の時間的関連を調べた.
- プライマリアウトカムには,血圧とインシデント高血圧が含まれており,二次的なアウトカムは,血管硬さの測定でした.
主要な成果:
- サイクル7におけるFWAとCFPWVの上昇は,サイクル8におけるシストリック血圧の上昇と関連していました.
- サイクル7におけるFWA,アグメンテーション指数,CFPWVの増加は,サイクル8におけるインシデント高血圧を予測した.
- サイクル7における初期血圧は,サイクル8におけるCFPWVを予測することはできませんでしたが,腕動脈の流れと流れ媒介の膨張は,発生高血圧と関連していました.
結論:
- 高動脈硬度,FWA,および増幅指数は,高血圧を発症するリスクの増加と関連しています.
- 初期血圧レベルは,主動脈硬化が時間の経過とともに進行することを独立して予測することはできません.
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