慢性心不全における無酸素値. 血液乳酸,呼吸器基礎,再現性,運動訓練への反応との関係
1Department of Medicine, Durham, NC 27710.
Circulation
|January 1, 1990
まとめ
ガス交換による無酸素値 (ATge) は,慢性心不全 (CHF) 患者における機能能力の信頼できる測定値である. 運動トレーニングはATgeを改善し,運動耐性を高め,ピーク酸素消費量 (VO2) を高めます.
科学分野:
- 心臓病学 心臓病学
- 運動生理学 運動生理学
- 肺内医学は肺内医学である.
背景:
- 慢性心不全 (CHF) の患者は運動耐性が低下し,機能障害に影響を及ぼします.
- ガス交換による無酸素値 (ATge) は,CHFにおける機能能力と治療応答を評価するための潜在的なバイオマーカーです.
- 運動中の呼吸器,血液動力,代謝の反応を理解することは,CHFの管理に不可欠です.
研究 の 目的:
- 慢性心不全 (CHF) の機能障害の尺度として,ガス交換 (ATge) による無酸素値を評価する.
- CHF患者および健康な個体におけるATge測定の再現性と信頼性を評価する.
- 運動トレーニングがATgeに与える効果と,CHF患者における運動耐性を測定する.
主な方法:
- 最大サイクリング運動テストは,64人のCHF患者と38人の対照群で実施され,呼吸器,血液動力,代謝の反応を測定しました.
- ATgeは,呼吸器等価法 (VE/VO2およびVE/VCO2) を用いて,18人のCHF患者および18人の対照群で特定されました.
- ATgeの再現性と観察者間の変動性が評価され,12人のCHF患者は4〜6ヶ月の運動訓練プログラムを受けました.
主要な成果:
- CHFの患者は,増えたデッドスペースと潮量比 (Vd/Vt) に関連した,二酸化炭素生産比 (VE/VCO2) に換気が増加したことを示した.
- ATgeは,ほとんどの患者および対照群で識別可能であり,良好な再現性と観察者間の低変動性を示した.
- 運動トレーニングはピークVO2を23%改善し,ATgeVO2を10.1ml/kg/minから12.1ml/minに増加させ,CHF患者の運動期間を延長しました.
結論:
- ガス交換による無酸素値 (ATge) は,慢性心不全 (CHF) の機能能力を評価するための再現可能で信頼できるパラメータです.
- 運動トレーニングは,ATgeを効果的に改善し,CHF患者の運動耐性を高めます.
- ATgeは,CHFの運動能力を改善することを目的とした治療的介入のモニタリングのための貴重なツールとして機能します.
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