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Fun30ヌクレオソーム改造機は,DNAの二重鎖の断端の切除を促進する

Xuefeng Chen1, Dandan Cui, Alma Papusha

  • 1Department of Molecular & Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Nature
|September 11, 2012
PubMed
まとめ

この研究は,Fun30をクロマチンを改造する重要な酵素として特定し,同類の再結合を通じてDNA二重鎖断裂 (DSB) 修復を促進します. Fun30は,Rad9.9のような阻害因子を克服することにより,切除プロセスを促進します.

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