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Updated: May 7, 2026

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
10:18

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

Published on: June 29, 2014

G(13) 媒介のシグナル伝達経路は,圧力過負荷が誘発した心臓の改造と心不全のために必要である

Mikito Takefuji1, Angela Wirth, Martina Lukasova

  • 1Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.

Circulation
|September 14, 2012
PubMed
まとめ

G 12/13 タンパク質ファミリー,特に Gα 13 は,圧力の過剰負荷によって引き起こされる心臓の改造と心不全への進行において極めて重要です. Gα(13) を非活性化することで,心筋縮および線維症から保護します.

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