補完系は,心不全性疾患における補完系である
M Yasuda1, K Takeuchi, M Hiruma
1First Department of Internal Medicine, Osaka City University Medical School, Japan.
Circulation
|January 1, 1990
まとめ
コンプリメントシステムの活性化は,急性心筋梗塞 (AMI) で発生し,心臓損傷に関連しています. 軽度のアクティベーションは不安定なアンギナでは見られますが,心臓機能障害のない安定したアンギナでは見られません.
科学分野:
- 心血管医学 心血管医学
- 免疫学 免疫学とは
- バイオケミストリー バイオケミストリー
背景:
- 急性心筋梗塞 (AMI) の後の組織損傷のメカニズムは不明である.
- 実験的なモデルは,AMIに関連するマイクロ血管およびマクロ血管損傷における補完系関与を示唆しています.
- 胸痛における補完体活性化の役割はよく定義されていません.
研究 の 目的:
- 心筋炎症の媒介者としてのコンプレメントシステムの役割を調査する.
- AMI,不安定性アンギナ,安定性アンギナ,および健康なボランティアの患者におけるコンプリメント活性化製品の定量化.
- コンプリメント活性化と心筋損傷の関連性を評価する.
主な方法:
- プラズマサンプルにおけるコンプレメント活性化製品 (C3d,C4d,Bb,SC5b-9) の定量化.
- 研究対象は,AMI患者31人,アンスタブルなアンギナ患者17人,安定したアンギナ患者19人,正常なボランティア20人でした.
- SC5b-9レベルとピーククレアチン・フォスフォキナーゼ,エジェクション分数,心不全状態の間の相関を分析した.
主要な成果:
- プラズマC3d濃度は,AMIおよび不安定性胸痛患者で上昇した (p<0.01).
- C4d,Bb,SC5b-9の血濃度は,AMI患者においてのみ増加した (p<0.01).
- 血SC5b-9濃度は,クレアチン・フォスフォキナーゼ (r=0.71) と逆のエジェクション分数 (r=-0.71) と相関しており,心不全のAMI患者では高かった.
結論:
- 補完系活性化はAMI後に明らかであり,心筋損傷と関連しています.
- 軽度の補完系活性化は,心機能障害のない不安定な胸痛で起こります.
- コンプリメントシステムは,安定した胸痛では活性化されません.
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