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Updated: May 12, 2026

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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RNF168は,H2A/H2AX上でK13-15をユビキチネートし,DNA損傷シグナル伝達を推進する

Francesca Mattiroli1, Joseph H A Vissers, Willem J van Dijk

  • 1Division of Biochemistry and Center for Biomedical Genetics, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Cell
|September 18, 2012
PubMed
まとめ

RNF168は,RNF8ではなく,DNA損傷応答中にK13-15のヒストンH2A/H2AXをモノビキチナートする. この特定のヒストンのユビキチネーションは,ユビキチンの鎖だけでなく,信号伝送に不可欠です.

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