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Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes
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糖尿病のβ細胞不全のメカニズムとして,臓β細胞の脱差別化

Chutima Talchai1, Shouhong Xuan, Hua V Lin

  • 1Department of Medicine, Columbia University, New York, NY 10032, USA.

Cell
|September 18, 2012
PubMed
まとめ

臓のベータ細胞のフォークヘッドボックスタンパク質1 (FoxO1) 欠乏は,細胞の脱差異ではなく死を引き起こすため,高血糖症を引き起こす. この発見は,ベータ細胞の分化を回復することで,糖尿病の治療が可能であることを示唆しています.

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