関連する実験動画
Updated: May 11, 2026
05:47
Isolation of Murine Lymph Node Stromal Cells
Published on: August 19, 2014
リンパ節における空間的に組織された多細胞の先天性免疫反応は,全身的病原体の拡散を制限する
Wolfgang Kastenmüller1, Parizad Torabi-Parizi, Naeha Subramanian
1Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. kastenmullerw@mail.nih.gov
Cell
|September 18, 2012
まとめ
リンパ節に戦略的に配置された先天性免疫細胞は,病原体を迅速に検出します. この早期の防御は,細菌が体全体に広がることを防ぎます.
科学分野:
- 免疫学 免疫学とは
- 生まれながらの免疫力
- リンパ系生物学 リンパ系生物学
背景:
- リンパ系は,流体と抗原を輸送し,病原体の拡散の潜在的な経路として機能します.
- リンパ節は,侵入する微生物に対する免疫反応を開始するための重要な場所です.
- リンパ節内の有効な先天性免疫反応は,全身の感染症を予防するために不可欠です.
研究 の 目的:
- リンパ節における細胞位置づけと細胞間通信が,先天的な免疫防御に果たす役割を調査する.
- リンパ節内の抗菌剤耐性に貢献する先天性リンパ球細胞のメカニズムを解明する.
- マクロファージによる病原体感知が,近くの先天性リンパ球の活性化にどのように影響するかを理解する.
主な方法:
- リンパ性シヌス内膜マクロファージに対するリンパ性細胞集団の空間分析.
- マクロファージによって生成される炎症体生成型サイトカイン (例えば,IL-18) の検出.
- 刺激を受けた先天性リンパ球によるインターフェロン-ガンマ (IFNγ) の分泌の評価.
- バクテリアの拡散への影響を観察するために,先天的な免疫応答ループの実験操作.
主要な成果:
- 様々な先天性リンパ性細胞 (NK細胞, γδT細胞,NKT細胞,先天性CD8+T細胞) は,センチネルマクロファグの近くに位置しています.
- マクロファージは,病原体を感知すると,炎症体に依存するIL-18および他のサイトカインを放出します.
- 近接は,先天性リンパ球による迅速なサイトカイン信号受容を可能にし,迅速なIFNγ分泌につながります.
- この先天的な免疫回路の障害は,リンパ系細菌の全身的拡散を促進します.
結論:
- 細胞の位置付けとリンパ節内の局所的なサイトカインシグナル伝達は,先天的な宿主防御に不可欠です.
- 病原体感知マクロファージによって活性化された先天性リンパ性細胞は,抗菌剤耐性を授与する.
- リンパ節は,先天的な免疫の活性部位として機能し,病原体の拡散を阻害するために不可欠です.
関連する概念動画
01:23Introduction to Lymphatic and Immune System
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
01:28Functions of the Lymphatic and Immune System
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:23Detailed Structure and Function of Lymph Nodes
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...