冠動脈疾患の危険因子としての仕事のストレス:個々の参加者のデータの共同メタ解析
Mika Kivimäki1, Solja T Nyberg, G David Batty
1Department of Epidemiology and Public Health, University College London, London, UK. m.kivimaki@ucl.ac.uk
Lancet (London, England)
|September 18, 2012
まとめ
仕事のストレスは,冠動脈疾患のリスクが高いことと関連しています. 仕事のストレスを防ぐことは役立つかもしれませんが,喫煙などの主要なリスク要因に対処するよりも効果は少ないです.
科学分野:
- 職業衛生は,健康に関するものです.
- 心血管疾患の疫学について
- 心理社会的リスク要因
背景:
- 仕事のストレスと冠動脈疾患 (CHD) に関する既存の研究は矛盾しており,出版と逆因果バイアスに関する懸念がある.
- このメタ解析は,包括的なデータセットを使用して,仕事のストレスとCHDの関連性を明らかにすることを目的とした.
研究 の 目的:
- 仕事のストレスと冠動脈疾患の発生率との関係を調査する.
- 公開されたデータと未公開のデータのメタ分析を通じて,以前の研究における潜在的なバイアスを解決する.
主な方法:
- 13件の欧州コホート研究 (1985年−2006年) の個人参加者データを分析した.
- 仕事のストレスは,検証されたアンケートを使って評価され,冠動脈性心疾患は,非致死性心筋梗塞または冠動脈性死を含む.
- 分析は,早期発症イベントを除外することによって,潜在的な逆因果関係を考慮した.
主要な成果:
- 仕事のストレスは,冠動脈性心疾患 (HR 1.23) のリスクの23%増加と関連していました.
- この関連性は,さまざまな混同要因を調整した後も,初期イベントを除いた分析でも依然として有意であった.
- 職務上のストレスに対する住民によるリスクは3.4%と推定された.
結論:
- 仕事のストレスは,冠動脈疾患の重要な危険因子です.
- 職場でのストレスの予防は,心臓病の発生率を低減させる可能性があるが,喫煙などの既定の危険因子を管理するよりも効果は低い.
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