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Updated: May 18, 2026

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小分子阻害剤によるヒトMDM2のN端のオーダーリング

Klaus Michelsen1, John B Jordan, Jeffrey Lewis

  • 1Molecular Structure & Characterization, Amgen, Inc., Thousand Oaks, California 91320, USA.

Journal of the American Chemical Society
|September 21, 2012
PubMed
まとめ

新しいピペリディノン阻害剤は,MDM2-p53複合体を破壊し,腫瘍抑制剤p53の機能を回復します. これらの強力ながん治療薬は,MDM2のN端を独特に誘導し,新しい合理的な薬物設計戦略を提供します.

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