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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
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Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

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トランジエント受容体ポテンシャル カノニカル-3チャネル依存性フィブロブラスト調節 心房細動における心房細動

Masahide Harada1, Xiaobin Luo, Xiao Yan Qi

  • 1Department of Medicine and Research Center, Montreal Heart Institute and Universite´ de Montre´al, Montreal, Quebec, Canada.

Circulation
|September 21, 2012
PubMed
まとめ

トランジエント受容体ポテンシャルカノニカル-3 (TRPC3) チャンネルは,心房動 (AF) で心筋線維芽細胞の活性化を誘導する. ピラゾール-3でTRPC3チャネルを遮断すると,体内ではAFを抑制し,犬のモデルでは疾患の進行を防ぐことができました.

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