飼い猫と野良猫の色素パターンを特定し,維持する
Christopher B Kaelin1, Xiao Xu, Lewis Z Hong
1HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
Science (New York, N.Y.)
|September 22, 2012
まとめ
科学者たちは,トランスメブランアミノペプチダゼQ (Taqpep) 遺伝子がキング・チーターを含む猫の毛皮のパターンの鍵であることを発見しました. この遺伝子は,Endothelin3 (Edn3) とともに,2段階の発達プロセスを通して,猫の多様なマークを説明します.
科学分野:
- 遺伝学 遺伝学とは
- 発達生物学 発達生物学について
- 動物学 動物学
背景:
- 猫の毛皮のパターンは,多様で周期的な変化を示しています.
- 飼い猫のタビーのパターンは,選択によって影響された保存された遺伝的メカニズムを示唆しています.
研究 の 目的:
- 飼い猫におけるタビーパターン変異の遺伝的根拠を特定する.
- 31種のフェリド種におけるコートパターンの多様性における特定された遺伝子の役割を調査する.
- 猫の毛皮のパターンの発達の基礎となる分子メカニズムを解明する.
主な方法:
- 飼い猫における遺伝子識別と配列決定.
- 31のフェリド種を対象とした比較ゲノム解析.
- ヒストロジック,ゲノム発現,およびトランスジェニックマウス研究.
- エンドセリン3 (Edn3) 発現パターンの分析.
主要な成果:
- トランスメブランアミノペプチダゼQ (Taqpep) は,家猫のタビーパターンに起因する遺伝子として特定されました.
- タクペプはまた,キング・チーターのユニークな斑点とストライプの表型の原因として特定されました.
- Endothelin3 (Edn3) のパラクリン発現は,局所的な色差を調整することが判明しました.
結論:
- 猫の毛皮のパターンの発達のための2段階のモデルが提案されています.
- Taqpepは,皮膚の発達中に周期的な前型を確立します.
- 微分Edn3表現は,その後,パターンを実装し,多様な猫の色彩を説明します.
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