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遠隔変異は,チミジラート合成酵素における協調したタンパク質の動きを妨害することによって,ヒドリド移転に影響する

Zhen Wang1, Thelma Abeysinghe, Janet S Finer-Moore

  • 1Department of Chemistry, University of Iowa, Iowa City, Iowa 52242-1727, USA.

Journal of the American Chemical Society
|October 5, 2012
PubMed
まとめ

タンパク質の柔軟性は,酵素機能の鍵である. チミジラート合成酵素 (TSase) の突然変異は,タンパク質の動きを妨害し,ヒドリド移転のための活性部位の先行組織を変化させることで活性性を低下させた.

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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