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関連する概念動画

Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of specific...
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...

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関連する実験動画

Updated: May 18, 2026

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs
09:37

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs

Published on: August 31, 2009

Elfn1は,CA1-インターニューロンシナプスにおける標的特異的な放出確率を調節する.

Emily L Sylwestrak1, Anirvan Ghosh

  • 1Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0366, USA.

Science (New York, N.Y.)
|October 9, 2012
PubMed
まとめ
この要約は機械生成です。

O-LM内ニューロンの細胞外レウシンに富んだリピートフィブロネクチン含有タンパク質1 (Elfn1) はシナプス形成を誘導する. ポストシナプス Elfn1 はプレシナプス解離の確率を制御し,ピラミッド型-O-LM シナプスの特異な特性を生み出します.

さらに関連する動画

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons
14:37

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons

Published on: September 30, 2014

Presynapse Formation Assay Using Presynapse Organizer Beads and “Neuron Ball” Culture
10:17

Presynapse Formation Assay Using Presynapse Organizer Beads and “Neuron Ball” Culture

Published on: August 2, 2019

関連する実験動画

Last Updated: May 18, 2026

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs
09:37

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs

Published on: August 31, 2009

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons
14:37

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons

Published on: September 30, 2014

Presynapse Formation Assay Using Presynapse Organizer Beads and “Neuron Ball” Culture
10:17

Presynapse Formation Assay Using Presynapse Organizer Beads and “Neuron Ball” Culture

Published on: August 2, 2019

科学分野:

  • 神経科学は神経科学である.
  • シナプスの可塑性
  • 分子生物学は分子生物学である.

背景:

  • シナプス伝達には,特定のシナプス特性の双方向信号が含まれる可能性があります.
  • ピラミッド型のニューロンは,ヒポキャンパスの内部ニューロンに独特の刺激シナプスを形成します.
  • O-LMインターニューロンへのシナプスは促進 (低解離確率),パーバルブミンインターニューロンへのシナプスは抑うつ (高解離確率) である.

研究 の 目的:

  • 標的特異のシナプス形成の基礎にある分子機構を調査する.
  • シナプス特性の調節における細胞外レウシンに富んだリピートフィブロネクチン含有1 (Elfn1) の役割を決定する.

主な方法:

  • 海馬内ニューロンにおけるElfn1の選択的発現分析.
  • シナプス解離の可能性を評価するための電気生理学的記録.
  • Elfn1がシナプス形成と性質に及ぼす機能的影響を調査する.

主要な成果:

  • 1 (Elfn1) を含有する細胞外レウシンに富んだリピートフィブロネクチンは,オリエンス-ラキュノスウム分子 (O-LM) 内ニューロンによって選択的に発現します.
  • ポストシナプス Elfn1 発現は,プレシナプス解離確率を調節する.
  • この規則は,ピラミッド型-O-LMシナプスの形成を促進する.

結論:

  • O-LM内ニューロンにおけるElfn1のポストシナプス発現は,標的特有のシナプス特性の確立に不可欠である.
  • Elfn1は,ポストシナプスニューロンからのシグナル伝達分子として作用し,シナプス前放出確率を調節します.
  • このメカニズムは,O-LMインターニューロンを標的とするピラミッド細胞のアクソンにユニークな機能的特徴を与える.