血友病の子供における身体活動と出血のリスクとの関連
Carolyn R Broderick1, Robert D Herbert, Jane Latimer
1Sydney Medical School, University of Sydney, Sydney, NSW, Australia. c.broderick@unsw.edu.au
JAMA
|October 11, 2012
まとめ
激しい運動は,血友病の子供の出血リスクの適度かつ一時的な上昇と関連しています. しかし,そのような活動に関連した出血の全体的な増加は小さい可能性があります.
科学分野:
- 小児血液学 小児血液学
- スポーツ医学 スポーツ医学
- 血流障害 血流障害 血流障害
背景:
- 血行不良の子どもでは,出血のリスクに関する懸念のため,身体活動はしばしば制限されます.
- 身体活動に関連した出血リスクの増加の正確な大きさは不明である.
研究 の 目的:
- 小児血友病患者の身体活動に関連した出血リスクの一時的な増加を定量化するために.
- 異なるカテゴリーの身体活動と出血事件の関連性を分析する.
主な方法:
- ヘモフィリアAまたはBを患っている104人の子供 (4~18歳) の前向きなコホートに組み込まれたケース・クロスオーバー研究です.
- 出血の8時間前の身体活動による被曝は,凝固因子レベルを調整した対照期間と比較した.
- アクティビティは衝突頻度と強度によって分類された.
主要な成果:
- カテゴリー2の活動 (バスケットボールなど) は,不活動に比べて出血のリスクが高く (OR,2.7) でした.
- カテゴリー3の活動 (例えば,レスリング) は,出血リスクのより大きな一時的な増加を示した (OR, 3.7).
- 凝固因子のレベルが1%上昇すると,出血頻度が2%減少することが関連していました.
結論:
- 強烈な身体活動は,血友病の子どもおよび青少年における出血リスクの比較的適度な増加と一時的に関連しています.
- 身体活動に起因する出血リスクの絶対的増加は,リスク増加の一時的な性質のために小さい可能性が高い.
関連する概念動画
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
2.5K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.5K
01:05Introduction to Hemostasis
17.9K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
17.9K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
15.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
15.7K
01:24Disorders of Hemostasis
2.8K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.8K
01:20Exercise and Cardiovascular Response
5.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
5.8K
01:30Venous Thrombosis IV: Nursing Management
392
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
392