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Updated: May 17, 2026

Thermodynamics of Membrane Protein Folding Measured by Fluorescence Spectroscopy
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Thermodynamics of Membrane Protein Folding Measured by Fluorescence Spectroscopy

Published on: April 28, 2011

デナチュラントの混合物の中で展開されたタンパク質の崩壊

Zhen Xia1, Payel Das, Eugene I Shakhnovich

  • 1Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, USA.

Journal of the American Chemical Society
|October 13, 2012
PubMed
まとめ

尿素にグアニジニウム塩化物 (GdmCl) などの第2のデナチュラントを加えると,予期せぬ形でタンパク質が崩壊する. このタンパク質の崩壊は,水害性残留物の埋葬と,タンパク質表面の近くでの変異性デナチュラント相互作用によって引き起こされる.

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