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Updated: May 17, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Published on: January 11, 2020

水性[18F]フッ化物によるPETのニッケル媒介酸化フッ化

Eunsung Lee1, Jacob M Hooker, Tobias Ritter

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|October 16, 2012
PubMed
まとめ

ニッケル複合体を用いた新しい1段階の酸化フッ素化法により,複雑な分子の効率的な後期フッ素化が可能になる. このブレークスルーは,ポジトロン放出トモグラフィー (PET) 画像処理のための新しいエージェントを開発するための実用的なアプローチを提供します.

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Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.