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Epistasis01:39

Epistasis

37.3K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
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Genetics of Speciation02:16

Genetics of Speciation

19.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
19.0K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
6.2K
Epistasis Analysis01:09

Epistasis Analysis

4.9K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K
Evolutionary Processes in Microbes01:26

Evolutionary Processes in Microbes

202
Microbial evolution occurs rapidly due to short generation times and a variety of genetic processes, including horizontal gene transfer, mutation, recombination, and genetic drift. These mechanisms collectively enable microbes to adapt swiftly to changing environments.Horizontal gene transfer (HGT) allows genes to move between different species and occurs through three main mechanisms: conjugation, transformation, and transduction. Conjugation involves direct cell-to-cell contact for DNA...
202
Evolution of New Traits in Microbes01:24

Evolution of New Traits in Microbes

199
Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...
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Updated: May 5, 2026

Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
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Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance

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分子進化の主要な要因としてのエピスタシス.

Michael S Breen1, Carsten Kemena, Peter K Vlasov

  • 1Bioinformatics and Genomics Programme, Centre for Genomic Regulation and Universitat Pompeu Fabra, 88 Dr Aiguader, Barcelona 08003, Spain.

Nature
|October 16, 2012
PubMed
まとめ

遺伝子変異が異なる遺伝的背景に異なった影響を及ぼすエピスタシスは,タンパク質の進化に普遍的です. ほとんどのアミノ酸の置換は,特定の種においてのみ有益であり,長期の分子進化に大きく影響を与えます.

科学分野:

  • 分子進化は分子進化である
  • 遺伝学 遺伝学とは
  • バイオケミストリー バイオケミストリー

背景:

  • 長期的な分子進化の主な原動力は,十分に理解されていません.
  • ポジティブ・セレクションはアミノ酸の置換に影響するが,エピスタシスの役割は不明である.

研究 の 目的:

  • 長期のタンパク質進化におけるエピスタシスの有病率を定量的に推定する.
  • アミノ酸の使用データを短期的な進化率と関連付けるため.

主な方法:

  • 16のオーガネルと核にコードされたタンパク質 (それぞれ≥1,000のオーソログ) の複数の配列アライメントの分析.
  • 観察されたアミノ酸置換率と,エピスタシスの欠如で予測された割合の比較.

主要な成果:

  • 平均的なタンパク質サイトには,約8種類の異なるアミノ酸が含まれています.
  • 測定されたアミノ酸置換率は,中性進化率より20倍低い.
  • アミノ酸置換の約90%は文脈依存であり,特定の遺伝的背景においてのみ中立または有益である.

結論:

  • エピスタシスは,タンパク質の進化における普遍的な力である.

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  • ほとんどのアミノ酸置換は,種間の文脈依存のフィットネス効果を示しています.
  • エピスタシスは,長期のタンパク質進化のテンポとモードを理解するために極めて重要です.