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Updated: May 17, 2026

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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機能化されたサイクロプロペンは,バイオオートゴーナル化学レポーターとして機能します

David M Patterson1, Lidia A Nazarova, Bryan Xie

  • 1Departments of Chemistry, University of California - Irvine, 92697, United States.

Journal of the American Chemical Society
|October 18, 2012
PubMed
まとめ

研究者は,バイオ分子にラベルを付けるための新しい化学レポーターとしてサイクロプロペンを開発しました. この新しいツールは,生物学的条件下では安定し,生細胞で有効であり,多用途の in vivo アプリケーションを可能にします.

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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