米国成人の脂質と脂質タンパク質の傾向,1988-2010年
Margaret D Carroll1, Brian K Kit, David A Lacher
1Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland 20782, USA. mdc3@cdc.gov
JAMA
|October 18, 2012
まとめ
米国の成人の血清脂質レベルは,1988年から2010年の間に好ましい傾向を示し,総コレステロール (TC) と低密度の脂質タンパク質コレステロール (LDL-C) が減少しました. 脂質低下薬の使用の増加は,コレステロールレベルにおけるこれらのポジティブな変化と一致しました.
科学分野:
- 心血管の健康についてです.
- 公共衛生の監視 公共衛生の監視
- 脂質代謝 脂質代謝とは
背景:
- 血清総コレステロール (TC) と低密度脂質タンパク質コレステロール (LDL-C) は,動脈硬化症とその臨床的続変に重要な貢献者である.
- 1988年から1994年,そして1999年から2002年の間に,米国の成人の平均TCとLDL-Cレベルは低下しました.
- この期間に,脂質低下薬の処方量が顕著に増加し,トリグリセリドのレベルが上昇し,高密度脂質タンパク質コレステロール (HDL-C) は安定していました.
研究 の 目的:
- 1988年から2010年までの米国成人の血清脂質プロフィールの動向を分析する.
- この期間中にTC,LDL-C,HDL-C,non-HDL-C,およびトリグリセリド値の変化を評価する.
- 脂質低下薬の使用率とその脂質傾向との関連を評価する.
主な方法:
- 1988年から1994年,1999年から2002年,2007年から2010年の間に実施された3つの異なる米国国立健康栄養調査 (NHANES) のデータを活用した.
- 分析されたTC,LDL-C,HDL-C,non-HDL-Cの平均レベル,および幾何学的平均トリグリセリドレベル.
- 研究期間中における脂質低下薬の使用率を調査した.
主要な成果:
- 平均TCは206 mg/dL (1988-1994) から196 mg/dL (2007-2010) に低下し,平均LDL-Cは129 mg/dLから116 mg/dLに低下した (線形傾向ではP <.001).
- 平均的なHDL-Cは50.7 mg/dLから52.5 mg/dLに大幅に増加した (線形動向ではP=.001).
- 脂質低下薬の使用率は3.4%から15.5%に急増した (線形動向ではP <.001).
結論:
- TCとLDL-Cの減少とHDL-Cの増加を含む血清脂質レベルにおける好ましい傾向は,1988年から2010年の間に米国の成人に観察されました.
- これらの改善は,脂質低下薬の使用の有意な増加とともに起こりました.
- この研究は,20年以上にわたり,米国成人人口の脂質プロファイルに関連した心血管疾患の危険因子のポジティブな変化を示しています.
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