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Updated: May 17, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
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Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Published on: July 17, 2020

2型糖尿病の治療の可能性のある高度に選択的で強力なPTP-MEG2阻害剤です

Sheng Zhang1, Sijiu Liu, Rongya Tao

  • 1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA.

Journal of the American Chemical Society
|October 19, 2012
PubMed
まとめ

研究者らは,細胞シグナル伝達に不可欠な酵素であるタンパク質チロシンフォスファタゼ (PTP) の強力で選択的な阻害剤を作成するための新しい化学戦略を開発しました. これらの新しいPTP阻害剤は,インスリン感受性およびグルコースホメオスタシスの改善に有望であることが示されています.

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Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

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