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Updated: May 5, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

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BTB-ZF因子は,リンパ性エフェクタープログラムを調節するために,E3リガゼクリンリンリンリン3を勧誘する

Rebecca Mathew1, Michael P Seiler, Seth T Scanlon

  • 1Committee on Immunology, Department of Pathology, The Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA.

Nature
|October 23, 2012
PubMed
まとめ

プロミエロサイト性白血病亜鉛指 (PLZF) とBCL6転写因子は,クリン3 (CUL3) を募集してクロマチンを修正する. この相互作用は,T細胞とB細胞の分化に不可欠であり,ある種の癌において役割を果たす可能性がある.

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Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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