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Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling
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Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling

Published on: August 1, 2016

ミオシン光鎖のリン酸化は,心臓のストレスへの適応に不可欠です

Sonisha A Warren1, Laura E Briggs, Huadong Zeng

  • 1Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610-0274, USA.

Circulation
|October 26, 2012
PubMed
まとめ

ユビキチン-プロテアソーム系による心筋ミオシンの軽鎖キナーゼ (cMLCK) の加速された分解は,心筋ミオシンの軽鎖2 (MLC2v) のリン酸化を減少させ,補償性高縮から心不全への移行を促します.

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