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Updated: May 17, 2026

CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy
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遺伝性ミトコンドリア疾患の生殖線遺伝子治療に向けて

Masahito Tachibana1, Paula Amato, Michelle Sparman

  • 1Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA.

Nature
|October 30, 2012
PubMed
まとめ

人間の卵細胞におけるミトコンドリアDNA (mtDNA) の交換は,スパインドル転送 (ST) を通じて可能である. この技術はmtDNAを成功裏に置き換え,正常な胚の発達と幹細胞の誘導を可能にし,遺伝性ミトコンドリア疾患の予防に希望を与えました.

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