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破壊的なマクロ分子阻害剤によるIgE受容体複合体の加速分解

Beomkyu Kim1, Alexander Eggel, Svetlana S Tarchevskaya

  • 1Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|October 30, 2012
PubMed
まとめ

新しく設計されたタンパク質阻害剤であるDARPin E2_79は,前型IgE-FcεRI複合体を積極的に解離し,伝統的な競争的阻害を超えてアレルギー反応をブロックする新しい戦略を提供します.

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