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Updated: May 17, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
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siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

ベックリン1のリン酸化によるオートファジーと腫瘍発生のアクト介的調節

Richard C Wang1, Yongjie Wei, Zhenyi An

  • 1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|November 1, 2012
PubMed
まとめ

フォスファチチチリノシトール3キナーゼ (PI3K) - アクト経路による異常なシグナル伝達は,がんを促進する. AktはBeclin 1をリン酸化し,オートファギーを阻害し,Beclin 1/14-3-3/vimentin複合体を形成することによって腫瘍の成長を促進する.

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