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Updated: May 17, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
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ミトコンドリアのAtpif1は,発達中の赤血球芽細胞におけるヘム合成を調節する

Dhvanit I Shah1, Naoko Takahashi-Makise, Jeffrey D Cooney

  • 1Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|November 9, 2012
PubMed
まとめ

ミトコンドリアタンパク質Atpif1は,ヘム合成に不可欠なフェロケラゼ (Fech) 酵素の活性を直接調節する. その欠乏はヘム産生を阻害し,貧血を引き起こし,潜在的に先天性 sideroblastic 貧血に寄与します.

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