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関連する概念動画

General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

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Updated: May 17, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Na&#239;ve CD4+ T Cells Using a TGF-&#946;-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

新たに開発されたFOXO1依存型転写プログラムにより,T (((reg) 細胞の機能を制御する.

Weiming Ouyang1, Will Liao, Chong T Luo

  • 1Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Nature
|November 9, 2012
PubMed
まとめ
この要約は機械生成です。

フォークヘッドボックスO1 (Foxo1) は,T (Treg) 細胞の機能を調節し,免疫ホメオスタシスを維持するために不可欠です. Treg細胞におけるFoxo1の削除は重度の炎症を引き起こし,Treg細胞の初期結合を超えてその重要な役割を強調する.

さらに関連する動画

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

関連する実験動画

Last Updated: May 17, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Na&#239;ve CD4+ T Cells Using a TGF-&#946;-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

科学分野:

  • 免疫学 免疫学とは
  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学

背景:

  • Foxp3によって標識された調節性T (Treg) 細胞は,免疫応答を抑制することによって免疫ホメオスタシスを維持します.
  • AktキナーゼとFoxo転写因子はTreg細胞の早期結合を調節しますが,成熟したTreg細胞の機能におけるそれらの役割は不明です.

研究 の 目的:

  • Treg細胞の恒常性およびコミットメント段階を超えた機能におけるFOXOタンパク質の役割を調査する.
  • Foxo1がTreg細胞機能と免疫ホメオスタシスを調節するかどうかを判断する.

主な方法:

  • トレグ細胞特異的なFoxo1.1のデリレーションを持つマウスを生成した.
  • 分析されたTreg細胞機能,免疫ホメオスタシス,および炎症反応.
  • Foxo1結合部位の全ゲノム分析を行った.

主要な成果:

  • トレグ細胞は高レベルのFOXO1と,Aktの活性化,FOXO1のリン酸化,核の排除が低下している.
  • トレグ細胞特異的なFoxo1の欠失は,Foxp3欠乏症と同様の致命的な炎症性疾患をもたらしたが,Treg細胞の喪失はなかった.
  • Foxp3.3によって直接調節されないIfngを含む約300のFoxo1標的遺伝子を特定しました.

結論:

  • Foxo1はTreg細胞機能と免疫ホメオスタシスの重要なレギュレータです.
  • Akt-Foxo1シグナル伝達経路は,Treg細胞機能に不可欠な新しい遺伝子プログラムを制御しています.
  • Foxo1は,Treg細胞数におけるFoxp3の役割とは独立して,免疫バランスの維持に重要な役割を果たします.