Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Comparison of frequency-resolved optical polarization gating induced by molecular alignment and Kerr effects.

Optics letters·2012
Same author

Direct transformation of simple enals to 3,4-disubstituted benzaldehydes under mild reaction conditions via an organocatalytic regio- and chemoselective dimerization cascade.

Chemistry (Weinheim an der Bergstrasse, Germany)·2012
Same author

[Digital anatomy of the perforator flap in the thigh].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery·2012
Same author

[Value of methylation-specific mutiplex ligation-dependent probe in the diagnosis of Prader-Willi syndrome].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2012
Same author

Elevated local TGF-β1 level predisposes a closed bone fracture to tuberculosis infection.

Medical hypotheses·2012
Same author

Modulation of P-glycoprotein expression by triptolide in adriamycin-resistant K562/A02 cells.

Oncology letters·2012

関連する実験動画

Updated: May 17, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

芽生えた酵母菌におけるミトコンドリアネットワークのサイズスケーリング

Susanne M Rafelski1, Matheus P Viana, Yi Zhang

  • 1Department of Biochemistry and Biophysics, University of California-San Francisco (UCSF), San Francisco, CA, USA. susanner@uci.edu

Science (New York, N.Y.)
|November 10, 2012
PubMed
まとめ

ミトコンドリアは酵母細胞,主に芽で成長し,世代を超えて安定したサイズ比を維持します. これにより,高齢の母親からのミトコンドリア分布の非対称性にもかかわらず,一貫した遺伝を保証します.

さらに関連する動画

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae
08:55

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae

Published on: July 19, 2021

Analysis of the Expression and Complexes Assembly of the Mitochondrial Respiratory Chain Proteins in the Fission Yeast Schizosaccharomyces pombe
08:07

Analysis of the Expression and Complexes Assembly of the Mitochondrial Respiratory Chain Proteins in the Fission Yeast Schizosaccharomyces pombe

Published on: May 2, 2025

関連する実験動画

Last Updated: May 17, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae
08:55

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae

Published on: July 19, 2021

Analysis of the Expression and Complexes Assembly of the Mitochondrial Respiratory Chain Proteins in the Fission Yeast Schizosaccharomyces pombe
08:07

Analysis of the Expression and Complexes Assembly of the Mitochondrial Respiratory Chain Proteins in the Fission Yeast Schizosaccharomyces pombe

Published on: May 2, 2025

科学分野:

  • 細胞生物学 細胞生物学
  • ミトコンドリアのダイナミクス
  • ブッダリング イーストモデル

背景:

  • ミトコンドリアは,適切な機能と遺伝のために,細胞の成長とともにスケールしなければならない重要な臓器です.
  • ミトコンドリアの含有量を維持することは,細胞生理学にとって極めて重要であり,娘細胞が適切なミトコンドリアを受け取ることを保証します.

研究 の 目的:

  • ミトコンドリアネットワークの大きさと芽生えた酵母における細胞の大きさとの関係を調査する.
  • 細胞分裂と老化中にミトコンドリアの含有量が細胞サイズに比例する方法を理解する.

主な方法:

  • 芽生えた酵母におけるミトコンドリアネットワークの大きさの定量分析.
  • ミトコンドリアと細胞のサイズ比を世代ごとに測定する.
  • 老化している母細胞とその芽のミトコンドリア遺伝パターンを追跡する.

主要な成果:

  • ミトコンドリアネットワークのサイズは,細胞のサイズと正の相関関係があり,スケーリングは主に芽に起こります.
  • ミトコンドリアと細胞のサイズ比は,年老いた母細胞において,次世代にわたって減少する.
  • 芽は,母親の年齢やミトコンドリアの含有量に関係なく,一貫して同様の平均ミトコンドリアと細胞のサイズ比を達成します.

結論:

  • 芽生える酵母は,ミトコンドリアの含有量と細胞のサイズとの間の安定したスケーリング関係を確立します.
  • 老齢期の母親における非対称的なミトコンドリア遺伝は,子細胞における一貫したオルガネル含有量を確保するために補償されます.
  • この調節メカニズムは,酵母集団における堅固な細胞生理学と遺伝を保証する.