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Updated: May 1, 2026

Covalent Labeling with Diethylpyrocarbonate for Studying Protein Higher-Order Structure by Mass Spectrometry
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タンパク質の折りたたみにより,二硫化物の形成が促進されます.

Pallav Kosuri1, Jorge Alegre-Cebollada2, Jason Feng2

  • 1Graduate Program in Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10027, USA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

Cell
|November 13, 2012
PubMed
まとめ

タンパク質二硫化イソメラーゼ (PDI) は,タンパク質の折り畳みを促進する. 新しい方法により,PDIは折り畳み遅れたネイティブ二硫化物結合を好み,誤折り畳みを防止し,コトランスレーションによる酸化折り畳みを可能にすることが明らかになった.

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