アクティブセンシングタスク中の感覚と運動のインプットの非線形 dendritic 統合
Ning-long Xu1, Mark T Harnett, Stephen R Williams
1Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA.
Nature
|November 13, 2012
まとめ
ニューロンは,複雑な処理のために活性型デンドライトを使用します. この研究は,マウスの活発な感知行動中に感覚情報と運動情報を統合する,層5ピラミッドニューロンにおける新しいデンドリティック非線形性を明らかにしています.
科学分野:
- 神経科学は神経科学である.
- 計算神経科学とは
- センサリー処理 センサリー処理
背景:
- アクティブなデンドライトは,神経の処理能力を高めます.
- 行動に関連した回路計算におけるデンドライトの役割は,ほとんど不明のままである.
- 層5のピラミッド型のニューロンは,異なる入力を受け取る複雑なデンドリート構造を持っています.
研究 の 目的:
- 活性感知行動におけるニューロンのデンドライトの役割を調査する.
- 感覚および運動情報統合に関わる新しいデンドリティック非線形性を特定する.
- オブジェクトローカライゼーションタスクの際に,層5のピラミッドニューロンにおけるインビヴォのデンドリット活性を調べる.
主な方法:
- オブジェクトの位置付けタスクを実行しているマウスの2フォトンカルシウムイメージング.
- バレル皮質の5層のピラミダルニューロンのデンドリット活性を記録する.
- デンドリット高原の潜在力と,感覚と運動の入力への依存を分析する.
主要な成果:
- 層5のピラミッド型のニューロンで,新しいグローバルデンドリティック非線形性が特定されました.
- 大幅のグローバルカルシウム信号は,アクティブタッチ時にアピカルタフトのデンドライトで観察されました.
- これらの信号は,デンドリット高原の潜在能力を示すものであり,振動的な感覚入力と主動運動皮質の活動の両方を必要とします.
結論:
- 層5のピラミッド型ニューロンは,相関する感覚および運動情報の非線形 dendritic 処理を示します.
- この dendritic nonlinearityは,アクティブセンセーション中の入力相関に基づいた計算に不可欠です.
- 行動中の哺乳類新皮質の活発なデンドリット計算の直接的な証拠を提供します.
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