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Updated: May 16, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
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CKIP-1は,PP2Aを勧誘することによって,II級ヒストン脱酸化酵素のリン酸化を調節することによって,心筋縮を抑制する

Shukuan Ling1, Qiao Sun, Yuheng Li

  • 1State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Haidian District, Beiqing Rd, Beijing, China.

Circulation
|November 16, 2012
PubMed
まとめ

カセインキナーゼ-2相互作用タンパク質-1 (CKIP-1) は,心筋縮を抑制する. CKIP-1欠乏症は心臓の膨張を悪化させ,過剰発現はHDAC4脱酸化を調節することによって心臓の膨張を予防する.

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