中枢神経系は代謝のコントロールをします
Martin G Myers1, David P Olson
1Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA. mgmyers@umich.edu
Nature
|November 16, 2012
まとめ
中枢神経系は,特に飢餓やホルモン欠乏の間,栄養処理と代謝制御において重要な役割を果たします. 最近の研究は,脳を強調しています.
科学分野:
- 神経科学は神経科学である.
- メタボリック・レギュレーション
- エンドクリノロジー エンドクリノロジー
背景:
- 伝統的に,栄養素の取り扱いの制御は,外周ホルモンの作用に起因していた.
- 中枢神経系 (CNS) の代謝における役割は,何十年も前から認識されてきました.
- 新興の証拠は,より広範なCNSが代謝調節に関与していることを示している.
研究 の 目的:
- 代謝制御における中枢神経系の一般的な役割を探求する.
- 代謝における様々なシグナルと下垂体回路の重要性を調査する.
- 代謝への脳の貢献が,特に特定の生理学的状態において,どのように明らかにされるかを理解する.
主な方法:
- 中枢神経系の代謝への関与に関する最近の発見のレビュー.
- 視床下部の回路とシグナル信号の分析.
- カタボリック状態とホルモン欠乏の間における代謝制御の検討.
主要な成果:
- CNSは,これまで考えられていたよりも代謝制御において,より一般的で重要な役割を果たしています.
- 脳の媒介による代謝調節には,特定のシグナルと下垂体回路が重要です.
- 脳の代謝機能は,飢餓やホルモン欠乏などの状態でより顕著になります.
結論:
- 中枢神経系は,全体の代謝制御に不可欠です.
- 視床下部の回路と外部信号は,脳の代謝機能の重要な媒介者です.
- 中枢神経系の役割を理解することは,特にストレスに関連する状態において,代謝の調節を理解するために非常に重要です.
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