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Updated: May 16, 2026

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
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テタリミシンAはMRSA活性抗生物質で,環境DNA遺伝子クラスタの誘発発現によって特定されました

Dimitris Kallifidas1, Hahk-Soo Kang, Sean F Brady

  • 1Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, United States.

Journal of the American Chemical Society
|November 20, 2012
PubMed
まとめ

研究者は,環境DNAから静かな遺伝子クラスタを活性化して,新しい抗生物質を発見しました. 特定の転写因子の過剰発現により,MRSAに対して有効な新型抗生物質であるテタリミシンAの隔離が可能になりました.

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