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Updated: May 16, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

FAD/葉酸依存型tRNAメチルトランスフェラーゼ:新しいメチル転送剤としてのフラビン

Djemel Hamdane1, Manuela Argentini, David Cornu

  • 1Laboratoire de Chimie des Processus Biologiques, CNRS-FRE 3488, Collège De France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France. djemel.hamdane@college-de-france.fr

Journal of the American Chemical Society
|November 20, 2012
PubMed
まとめ

TrmFOは独特のtRNAメチルトランスフェラーゼである. 研究者らは,TrmFO内の活性メチル化剤を特定し,メチレン-FADを用いたRNA改変のための新しいメカニズムを明らかにした.

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Transfer RNA Synthesis02:36

Transfer RNA Synthesis

One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Transfer RNA Synthesis02:36

Transfer RNA Synthesis

One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
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Phase II Reactions: Methylation Reactions

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