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Updated: May 16, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
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多能性再プログラム因子のゲノムとの初期接触の促進要因と阻害要因

Abdenour Soufi1, Greg Donahue, Kenneth S Zaret

  • 1Department of Cell and Developmental Biology, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Building 421, Rooms 131-132, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5157, USA.

Cell
|November 20, 2012
PubMed
まとめ

転写因子Oct4,Sox2,Klf4,c-Myc (OSKM) が細胞を再プログラムする. ゲノムへの初期OSKM結合は,抑制性染色体によって制限されるが,先駆的な因子Oct4,Sox2,Klf4が再プログラミングを容易にする.

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