癌との戦争で失われた仲介者
1Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. x4guo@ucsd.edu
Cell
|November 27, 2012
まとめ
メディエーターサブユニットMED12の喪失は,トランスフォーミング成長因子β (TGF-b) 信号伝達を活性化することによって,予期せぬ抗がん薬剤耐性を引き起こします. TGF-bを阻害すると,がん細胞が再敏感になり,新しい組み合わせ療法戦略が提供されます.
科学分野:
- 分子生物学は分子生物学である.
- がん研究 がん研究
- 細胞シグナル伝達 細胞信号伝達
背景:
- 媒介体複合体は,転写の調節に極めて重要です.
- MED12は,メディエーター複合体の重要なサブユニットです.
- 薬剤耐性は,がん治療における大きな課題です.
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