Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

582
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
582
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.8K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.8K
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

1.1K
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
1.1K
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

1.1K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.1K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.3K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.3K
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

17.1K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
17.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Nitrous oxide abuse prevalence, mechanisms, treatments and prevention.

Current medical research and opinion·2026
Same author

Identification and Characterization of Mitragynine or 7-Hydroxymitraynine Oral Dosage Form Products That Appeal to Children.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same author

Compounded Semaglutide and Tirzepatide Products Use Unique Formulations but Efficacy and Safety Largely Unknown.

The Annals of pharmacotherapy·2026
Same author

Nonswallowed Kratom-Derived Products: Unlawful Dietary Supplements That Endanger Public Health.

Public health reports (Washington, D.C. : 1974)·2026
Same author

Transdermal "Natural GLP-1" Dietary Supplements Violate Law and Place Patients at Risk.

The Annals of pharmacotherapy·2026
Same author

Correction: Use of SGLT2 Inhibitors in Pediatric Heart Failure: A Multi-Eenter Study.

Pediatric cardiology·2025

関連する実験動画

Updated: Mar 29, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

5.2K

スタチンが骨格筋機能に与える影響

Beth A Parker1, Jeffrey A Capizzi, Adam S Grimaldi

  • 1Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT, USA.

Circulation
|November 28, 2012
PubMed
まとめ

高用量アトルバスタチンは,健康な個体において,筋肉の強さや運動能力を損なわなかった. しかし,スタチンは筋肉の苦情や軽度の筋肉損傷を増加させ,さらなる研究が必要であることを示唆しました.

さらに関連する動画

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

12.4K

関連する実験動画

Last Updated: Mar 29, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

5.2K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

12.4K

科学分野:

  • 心臓病学 心臓病学
  • 神経学 神経学とは
  • 運動生理学 運動生理学

背景:

  • 臨床医はしばしばスタチンが筋肉痛を引き起こすと疑っているが,臨床試験では一貫してこれが示されていない.
  • 骨格筋の機能とパフォーマンスに対するスタチンの影響については,さらなる調査が必要です.

研究 の 目的:

  • 健康で,スタチンを服用した事のない個人の骨格筋機能とパフォーマンスに対する高用量アトルバスタチンの影響を評価する.
  • アトルバスタチンが筋肉の強さ,運動能力,およびクレアチンキナーゼレベルに影響するかどうかを評価する.

主な方法:

  • STOMP研究には,アトルバスタチン80mgまたはプラセボを6ヶ月間投与された,スタチン未使用の健康な被験者420人が参加しました.
  • 測定には,クレアチンキナーゼ,運動能力,筋肉強さ,治療前のおよび後の症状評価が含まれていました.

主要な成果:

  • アトルバスタチンは平均クレアチンキナーゼ濃度 (P<0,0001) を増加させましたが,筋肉の強さや運動能力を有意に変化させませんでした.
  • アトルバスタチンを服用した被験者は,プラセボと比較して,筋痛 (19対10; P=0.05) を報告した.
  • アトルバスタチンを服用した筋痛患者では,いくつかの変数で筋肉の強度が低下しましたが,これはプラセボと比較して統計的に有意ではありませんでした.

結論:

  • 6ヶ月間高用量のアトルバスタチンは,健康な被験者の筋肉の強さや運動能力を低下させません.
  • この研究は,スタチンが筋肉の苦情 (筋痛) を増加させ,肌の軽い損傷を引き起こす可能性があることを確認した.
  • 長期にわたる高用量スタチンの使用が筋肉の健康に与える影響を調べるためにさらなる研究が推奨されています.