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Updated: May 16, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
07:38

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Published on: September 25, 2017

癌に関連したニトロサミンの超分子センサー

Tsuyoshi Minami1, Nina A Esipenko, Ben Zhang

  • 1Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, United States.

Journal of the American Chemical Society
|December 1, 2012
PubMed
まとめ

この研究では,がん関連タイプを含むニトロサミンの検出と定量化のための新しい光測定法が導入されています. この方法は,クキュルビット[n]ウリル探査機を使用して,これらの検出が難しい化合物を高精度で識別します.

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関連する概念動画

2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.