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関連する概念動画

Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...

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関連する実験動画

Updated: May 16, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

エクソン・スプライス・エンハンスターは,IGF2:IGF2R結合部位の構造と機能の進化を原始化します.

Christopher Williams1, Hans-Jürgen Hoppe, Dellel Rezgui

  • 1Department of Organic and Biological Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.

Science (New York, N.Y.)
|December 1, 2012
PubMed
まとめ
この要約は機械生成です。

ゲノムインプリントと胎盤の発達は,親の対立によって進化した. モノトリームにおけるエクソン・スプライス・エンハンスターの進化は,予想外にもIGF2RがIGF2と結合することを可能にし,この衝突を誘発した.

さらに関連する動画

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

関連する実験動画

Last Updated: May 16, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

科学分野:

  • 進化生物学の進化生物学について
  • 遺伝学 遺伝学とは
  • 発達生物学 発達生物学とは

背景:

  • 胎盤の発達とゲノムインプリントは,子孫の資源配分に関する親の紛争と関連しています.
  • インプリントされた遺伝子IGF2とIGF2Rは,成長 (IGF2) とその抑制 (IGF2R) を調節する.
  • 非哺乳類のIGF2Rは,IGF2がCDループを通じてIGF2Rと結合するモノトレームとは異なり,IGF2を認識しません.

研究 の 目的:

  • IGF2RによるIGF2結合の進化的起源を調査する.
  • 結合親和性における構造変化の役割を理解する.
  • エクソン・スプライス・エンハンサー (ESE) の進化とゲノムインプリントの発生との関連を調査する.

主な方法:

  • 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析. 比較ゲノム分析.
  • タンパク質-リガンド相互作用の構造モデリング.
  • DNA配列とその機能的役割の分析.

主要な成果:

  • モノトリームでは,IGF2R CDループをコードするDNAは,エクソンスプライスエンハンサー (ESE) として作用する.
  • 結合ループ (AB,HI,FG) の構造的変更により,セリアン哺乳類のIGF2結合親和性が強化された.
  • ESEの進化は,IGF2RによるIGF2の初期,偶然の結合につながったと考えられている.

結論:

  • モノトリムにおけるESEの進化は,IGF2とIGF2Rの初期相互作用を容易にした可能性が高い.
  • この相互作用は,IGF2Rを親の対立に巻き込み,ゲノムインプリントを推進している可能性がある.
  • その後のインプリントは,IGF2RのIGF2.2への親和性の成熟を加速した可能性がある.