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Updated: May 10, 2026

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Ca2+は,脂質の電荷特性を調節することによって,T細胞受容体活性化を調節する

Xiaoshan Shi1, Yunchen Bi, Wei Yang

  • 1State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Nature
|December 4, 2012
PubMed
まとめ

カルシウムイオン (Ca2+) はアニオン系フォスホリピドに直接結合し,T細胞抗原受容体-CD3複合体 (TCR) 機能を調節する. このCa2+結合は,膜からCD3細胞質ドメインを放出し,チロシンリン酸化とT細胞活性化感性を高めます.

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