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Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

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Updated: May 16, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
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Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

複雑な世界におけるトランスクリプトームのダイナミクスのモデリング

Philipp A Jaeger1, Colleen Doherty, Trey Ideker

  • 1Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.

Cell
|December 11, 2012
PubMed
まとめ
この要約は機械生成です。

科学者は,環境要因による米の遺伝子発現の変化を予測することができます. 転写反応のモデリングにおけるこの突破は,現実世界の条件下で他の生物の反応を予測する可能性を秘めています.

さらに関連する動画

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Polysome Purification from Soybean Symbiotic Nodules
07:02

Polysome Purification from Soybean Symbiotic Nodules

Published on: July 1, 2022

関連する実験動画

Last Updated: May 16, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Polysome Purification from Soybean Symbiotic Nodules
07:02

Polysome Purification from Soybean Symbiotic Nodules

Published on: July 1, 2022

科学分野:

  • ゲノミクスゲノミクスとは
  • 環境科学 環境科学
  • 植物生物学 植物生物学

背景:

  • 環境刺激による遺伝子発現の変化を予測することは,複雑な課題です.
  • これらの反応を理解することは,農業と生態学にとって極めて重要です.

研究 の 目的:

  • 異なる環境条件下で米の全ゲノム的なmRNA発現変化を予測するためのモデルを開発する.
  • 制御不能な環境にさらされた生物における転写反応を予測する能力を向上させる.

主な方法:

  • 先進的な計算モデリング技術を活用した.
  • 様々な環境刺激にさらされた米の全ゲノム mRNA発現データを分析した.

主要な成果:

  • 米における全ゲノム的なmRNA発現変化をモデル化することに成功した.
  • 環境変数に対する転写反応を予測する可能性を実証した.

結論:

  • 長野氏と同僚の研究は,予測生物学における重要な進歩をもたらします.
  • この研究は,現実世界の環境で様々な生物の遺伝子発現を予測する見込みがある.