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Updated: May 16, 2026

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
07:50

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

Published on: August 29, 2018

ゲルムラインDNA脱メチル化ダイナミクスと,5-ヒドロキシメチルサイトシンによるインプリント消去

Jamie A Hackett1, Roopsha Sengupta1, Jan J Zylicz1,2

  • 1Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, United Kingdom.

Science (New York, N.Y.)
|December 11, 2012
PubMed
まとめ

マウスの原始生殖細胞 (PGC) は,TET1/TET2.2.によって誘発される,5-hydroxymethylcytosine (5hmC) 変換を通じてDNAメチレーションを消去する. この表遺伝的再プログラミングは,トーティポテンシーのためにゲノムをリセットしますが,一部の要素は脱メチル化から逃れ,潜在的に世代を超えた遺伝を可能にします.

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Selective Capture of 5-hydroxymethylcytosine from Genomic DNA

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