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Updated: May 16, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
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β-ヒドロキシブチラートによる酸化ストレスの抑制は,内生ヒストン脱酸化酶阻害剤である

Tadahiro Shimazu1, Matthew D Hirschey, John Newman

  • 1Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|December 11, 2012
PubMed
まとめ

ケトン体であるd-β-ヒドロキシブチラート (βOHB) は,ヒストン脱酸化酶 (HDAC) のクラスIを阻害し,ヒストンのアセチル化を増加させます. この代謝調節は,鍵となる遺伝子を活性化することによって,酸化ストレスに対する耐性を高めます.

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Histone Modification02:32

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