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Updated: May 15, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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Published on: September 18, 2014

サイクルGMP-AMP合成酵素は,タイプIインターフェロン経路を活性化する細胞性DNAセンサーです

Lijun Sun1, Jiaxi Wu, Fenghe Du

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|December 22, 2012
PubMed
まとめ

細胞塩基DNAは,周期的なGMP-AMP (cGAMP) 生産を通じて免疫反応を誘発する. 研究者らは,cGAMP合成酵素 (cGAS) を,STINGの活性化とインターフェロン産生と関連付け,責任ある酵素として特定した.

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