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Updated: May 11, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

多数の自閉症関連遺伝子は,シナプス・スカフォルド (PSD-95のシナプス・スカフォルド) のプロテアソモール分解によるシナプス除去を媒介する

Nien-Pei Tsai1, Julia R Wilkerson, Weirui Guo

  • 1Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|December 25, 2012
PubMed
まとめ

ミオサイト増強因子2 (MEF2) と脆弱X精神障害タンパク質 (FMRP) は,プロトカデリン10 (Pcdh10) を経由してシナプス除去を制御する. この経路はPSD-95の退化を含み,FMRP欠乏性ニューロンでは破壊され,自閉症遺伝子の役割を強調しています.

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